Obstructive Coronary Artery Disease

Our research aims to improve survival following myocardial infarction, reduce procedural complications, optimise complex coronary intervention and deliver more personalised treatment strategies through advanced imaging and applied coronary physiology.

Coronary artery disease remains the leading cause of death worldwide despite major advances in diagnosis and treatment. At ORIIC, we develop and evaluate innovative catheter-based therapies, intracoronary imaging techniques and physiology-guided interventions to improve the treatment of patients presenting with acute coronary syndromes and complex coronary disease. Our research spans the entire patient pathway to optimising complex PCI and developing next-generation reperfusion strategies.

Research Focus

Acute Coronary Syndromes

Understanding STEMI and NSTEMI pathophysiology and improving emergency therapies.

Primary PCI & Reperfusion

Optimising reperfusion therapies to minimise myocardial injury and no reflow.

Complex Percutaneous Coronary Interventions

Calcified lesions, bifurcations, chronic coronary disease and advanced intervention.

Intracoronary Imaging

OCT and IVUS to guide PCI and understand disease mechanisms.

CAPTURE AMI

Catheter-Based Sustained Mechanical Thrombectomy During Primary PCI.

Featured Projects

RETRIEVE AMI

Evaluation of coronary stent retriever technology in STEMI using OCT-derived thrombus assessment

REVITALISE AMI

Novel strategies to prevent microvascular obstruction following reperfusion with CorFlow technology.

PiCSO-AMI

International randomised trial evaluating PiCSO® as an adjunct to primary PCI to reduce infarct size in anterior STEMI

OPTIMAL

International randomised trial evaluating IVUS-guided PCI to optimise outcomes in unprotected left main coronary artery disease.

OxAMI-PiCSO

Evaluating PiCSO® to reduce infarct size and improve microvascular function before stenting in anterior STEMI.

Microvascular Dysfunction & Refractory Angina

Coronary microvascular dysfunction is an increasingly recognised cause of angina, myocardial ischaemia and adverse cardiovascular outcomes, often affecting patients without obstructive coronary artery disease. At ORIIC, we combine advanced invasive physiology, multimodality imaging and novel device-based therapies to improve the diagnosis, understanding and treatment of coronary microvascular disease and refractory angina.

Our research aims to improve at improve quality of life, by advancing the diagnosis and treatment of coronary microvascular disease through precision physiology and innovative therapies.

Coronary Microvascular Dysfunction

Research Focus

Investigating endothelial dysfunction and coronary vasomotor abnormalities.

Coronary Microvascular Dysfunction

Improving the diagnosis and understanding of ischaemia without obstructed coronary arteries

Developing physiology-guided approaches for assessing coronary microvascular function.

Invasive Coronary Physiology

Refractory Angina Management

Evaluating innovative therapies to improve symptoms & perfusion in refractory angina patients.

Featured Projects

REDEFINE CMD

Prospective study evaluating advanced invasive physiology to improve the diagnosis and phenotyping of coronary microvascular dysfunction.

EuroCRAFT

European multicentre registry on coronary physiology and contemporary management of patients with coronary microvascular dysfunction and INOCA.

COSIRA II

International randomised trial evaluating the Coronary Sinus Reducer for the treatment of patients with refractory angina.

Hypertension & Vascular Biology

Hypertension remains the leading modifiable risk factor for cardiovascular disease worldwide. ORIIC develops innovative catheter-based therapies, advanced vascular imaging and translational research to improve the diagnosis and treatment of resistant hypertension and vascular disease. Our programme combines renal denervation, cardiac and vascular CT, imaging biomarkers and vascular biology to deliver more personalised therapies and improve long-term cardiovascular outcomes.

Our research aims to improve blood pressure control, reduce cardiovascular risk and personalise the treatment of resistant hypertension through advanced imaging and innovative catheter-based therapies.

Research Focus

Resistant Hypertension

Developing new strategies for patients with treatment-resistant hypertension.

Renal Denervation

Advancing catheter-based renal denervation through research & procedural innovation.

Using advanced CT imaging to optimise procedural planning and patient selection for renal denervation. Developing imaging biomarkers and AI tools to personalise hypertension treatment.

CT-Guided Procedural Planning

Featured Projects

SPYRAL AFFIRM/SWYFT

International programme evaluating the safety and efficacy of radiofrequency-renal denervation for uncontrolled hypertension.

PARADISE GPS

International programme evaluating the safety and efficacy of ultrasound-renal denervation for uncontrolled hypertension.

MOLTEN

Prospective study evaluating CT-guided renal denervation planning and imaging biomarkers to optimise procedural outcomes.

Precision Cardiovascular Imaging & Diagnostics

Our research aims to improve blood pressure control, reduce cardiovascular risk and personalise the treatment of resistant hypertension through advanced imaging and innovative catheter-based therapies.

Precision cardiovascular medicine relies on combining advanced imaging, invasive diagnostics and computational technologies to better understand cardiovascular disease and tailor treatment to each patient. At ORIIC, we integrate cardiac CT, intracoronary imaging, coronary physiology and artificial intelligence to improve diagnosis, optimise procedural planning and develop more personalised catheter-based therapies across multiple cardiovascular diseases.

Research Focus

Cardiac CT & 3D Reconstruction

Advancing cardiac CT for diagnosis, procedural planning and personalised cardiovascular interventions.

Intracoronary Imaging & Coronary Physiology

Using high-resolution intracoronary imaging and coronary physiology technolgies to optimise PCI, personalise treatment and understand coronary pathology.

Artificial Intelligence & Computational Imaging

Developing AI-enabled imaging biomarkers and computational tools for personalised cardiovascular care.

Featured Projects

MOLTEN

Prospective study evaluating CT-guided renal denervation planning and imaging biomarkers to optimise procedural outcomes.

PREDICT CSR

Prospective study evaluating CT-guided renal denervation planning and imaging biomarkers to optimise procedural outcomes.

Contact

Get in touch for collaboration and inquiries.

Connect

contact@oriic.co.uk

© ORIIC

ORIIC is the public identity of an established multidisciplinary cardiovascular research group bringing together members from Oxford University Hospitals NHS Foundation Trust, the University of Oxford and collaborating institutions. Individual research activities remain governed by their respective sponsoring institutions.